Publications
Pre-Prints
"Optical control of sphingolipid biosynthesis using photoswitchable sphingosines"
Matthijs Kol, Alexander J.E. Novak, Johannes Morstein, Christian Schröer, Tolulope Sokoya, Svenja Mensing, Sergei M. Korneev, Dirk Trauner, Joost C.M. Holthuis, under review.
BioRxiv: https://doi.org/10.1101/2024.10.24.619506
"Optical Control of Membrane Fluidity Modulates Membrane Secretion"
Noemi Jiménez-Rojo, Suihan Feng, Johannes Morstein, Stefanie D. Pritzl, Takeshi Harayama, Antonino Asaro, Nynke A. Veprek, Christopher J. Arp, Martin Reynders, Alexander J. E. Novak, Evgeny Kanshin, Beatrix Ueberheide, Theobald Lohmüller, Howard Riezman, Dirk Trauner, in revision.
BioRxiv: https://doi.org/10.1101/2022.02.14.480333
Publications
44. "Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis"
Mario Amatruda, Damien Marechal, Mar Gacias, Maureen Wentling, Sarah Turpin-Nolan, Johannes Morstein, Mohammed Moniruzzaman, Jens C. Brüning, Norman J. Haughey, Dirk H. Trauner, Patrizia Casaccia, Glia 2024, in press. [DOI]
43. " Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist."
Federica Liccardo, Johannes Morstein, Ting-Yu Lin, Julius Pampel, Kevan M. Shokat, Roshanak Irannejad, PNAS 2024, 121, e2404243121. [DOI]
42. "Targeting Ras-, Rho-, and Rab-Family GTPases via a Conserved Cryptic Pocket"
Johannes Morstein, Victoria Bowcut, Micah Fernando, Yue Yang, Lawrence Zhu, Meredith L. Jenkins, John T. Evans, Keelan Z. Guiley, D. Matthew Peacock, Sophie Krahnke, Zhi Lin, Katrine A. Taran, Benjamin J. Huang, Andrew G. Stephen, John E. Burke, Felice C. Lightstone, Kevan M. Shokat, Cell 2024, 187, 1-14. [DOI]
Related News: [C&EN] [UCSF News]
41. "Optical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide"
Johannes Morstein, Alexander Amatuni, Anton Shuster, Wolfgang Kuttenlocher, Tongil Ko, Daniel Abegg, Michael Groll, Alexander Adibekian, Hans Renata, Dirk Trauner, Angew. Chem. Int. Ed. 2024, 63, e202314791. [DOI]
40. "Direct Modulators of K-Ras-Membrane Interactions"
Johannes Morstein, Rebika Shrestha, Que N. Van, César A. López, Neha Arora, Marco Tonelli, Hong Liang, De Chen, Yong Zhou, John F. Hancock, Andrew G. Stephen, Thomas J. Turbyville, Kevan M. Shokat, ACS Chem. Biol. 2023, 18, 2082-2093. [DOI]
Related News: [NCI Ras Dialogue]
39. "Chemical Neurobiology"
Johannes Morstein, Dirk Trauner, In "Advanced Chemical Biology", Wiley VCH 2023, 695-722. [DOI]
38. "Development of Light Activated LXR Agonists"
Tufan K. Mukhopadhyay, Sabine Willems, Christopher J. Arp, Johannes Morstein, Caleb T. Haake, Daniel Merk, Dirk Trauner, ChemMedChem 2023, 18, e202200647. [DOI]
37. "Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes"
Jacob Simon, Miriam Schwalm, Johannes Morstein, Dirk Trauner, Alan Jasanoff, Nat. Biomed. Eng. 2023, 7, 313-322. [DOI]
36. "Optical Control of Translation with a Puromycin Photoswitch"
Tongil Ko, Mauricio Oliveira, Jessica M. Alapin, Johannes Morstein, Eric Klann, Dirk Trauner, J. Am. Chem. Soc. 2022, 144, 21494-21501. [DOI]
35. "Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation"
Johannes Morstein, Taysir Bader, Ariana L. Cardillo, Julian Schackmann, Sudhat Ashok, James L. Hougland, Christine A. Hrycyna, Dirk Trauner, Mark D. Distefano, ACS Chem. Biol. 2022, 17, 2945-2953. [DOI]
34. "Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity"
Johannes Morstein, Alice Capecchi, Konstantin Hinnah, ByungUk Park, Jerome Petit-Jaques, Reid C. Van Lehn, Jean-Louis Reymond, Dirk Trauner, J. Am. Chem. Soc. 2022, 144, 18532-18544. [DOI]
Related News: [In the pipeline] [Nature]
33. "Postsynthetic Photocontrol of Giant Liposomes via Fusion-Based Photolipid Doping"
Stefanie D. Pritzl, Johannes Morstein, Sophia Kahler, David B. Konrad, Dirk Trauner, Theobald Lohmüller, Langmuir 2022, 38, 11941-11949. [DOI]
32. "Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile"
Ziyang Zhang, Johannes Morstein, Andrew K. Ecker, Keelan Z. Guiley, Kevan M. Shokat, J. Am. Chem. Soc. 2022, 144, 15916-15921. [DOI]
31. "Optical Control of Neuronal Activities with Photoswitchable Nanovesicles"
Hejian Xiong, Kevin A. Alberto, Jonghae Youn, Jaume Taura, Johannes Morstein, Xiuying Li, Yang Wang, Dirk Trauner, Paul A. Slesinger, Steven O. Nielsen, Zhenpeng Qin, Nano Res. 2022, https://doi.org/10.1007/s12274-022-4853-x. [DOI]
30. "Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor"
Johannes Morstein, Giovanna Romano, Belinda Hetzler, Ambrose Plante, Caleb Haake, Joshua Levitz, Dirk Trauner, Angew. Chem. Int. Ed. 2022, e202117094. [DOI]
29. "Photopharmacological control of cell signaling with photoswitchable lipids"
Tufan K. Mukhopadhyay, Johannes Morstein, Dirk Trauner, Curr. Opin. Pharmacol. 2022, 63, 102202. [DOI]
28. "Optical Control of Glycerophospholipids and Sphingolipids"
Dirk Trauner, Johannes Morstein, CHIMIA 2021, 75, 1022-1025. [DOI]
27. "Cholesterol and sphingomyelin are critical for Fcg receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages"
Arielle M. Bryan, Jeehyun K. You, Guangtao Li, JiHyun Kim, Ashutosh Singh, Johannes Morstein, Dirk Trauner, Nívea Pereira de Sá, Tyler G. Normile, Amir M. Farnoud, Erwin London, Maurizio Del Poeta, J. Biol. Chem. 2021, 297, 101411. [DOI]
26. "Optical Control of Phosphatidic Acid Signaling"
Reika Tei, Johannes Morstein, Andrej Shemet, Dirk Trauner, Jeremy Baskin, ACS Cent. Sci. 2021, 7, 1205-1215. [DOI]
25. "A Photohormone for Light-Dependent Control of PPARa in Live Cells"
Sabine Willems, Johannes Morstein, Konstantin Hinnah, Dirk Trauner, Daniel Merk, J. Med. Chem. 2021, 63, 10908-10920. [DOI]
24. "How Photoswitchable Lipids Affect the Order and Dynamics of Lipid Bilayer and Embedded Proteins"
Mahmoudreza Doroudgar, Johannes Morstein, Johanna Becker-Baldus, Dirk Trauner, Clemens Glaubitz, J. Am. Chem. Soc. 2021, 143, 9515-9528. [DOI]
23. "Efficient Loading and Drug Release from a Photoactivatable Lipid Nanoparticle"
Nisha Chander, Johannes Morstein, Jan S. Bolten, Andrej Shemet, Pieter R. Cullis, Dirk Trauner, Dominik Witzigmann, Small 2021, 2008198. [DOI]
22. "Epithelia-Sensory Neuron Crosstalk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine"
Yong Chen, Zi-Long Wan, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, Qian Zeng, Sara L. Morales-Lázaro, Carlene Moore, Ying-Ai Jin, Huang-He Yang, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Manal Abdelmalek, Anna Mae Diehl, Piotr Milkiewicz, Andreas E. Kremer, Jennifer Y. Zhang, Andrea Nackley, Tony E. Reeves, MeiChuan Ko, Ru-Rong Ji, Tamara Rosenbaum, Wolfgang Liedtke, Gastroenterology 2021, 161, 301-317. [DOI]
21. "Short Photoswitchable Ceramides Enable Optical Control of Apoptosis"
Johannes Morstein, Matthijs Kol, Alexander J. E. Novak, Suihan Feng, Shadi Khayyo, Konstantin Hinnah, Nasi Li-Purcell, Grace Pan, Benjamin M. Williams, Howard Riezman, G. Ekin Atilla-Gokcumen, Joost C. M. Holthuis, Dirk Trauner, ACS Chem. Biol. 2021, 16, 452-456. [DOI]
20. "Photoswitchable Lipids"
Johannes Morstein, Anna C. Impastato, Dirk Trauner, ChemBioChem 2021, 22, 73-83. [DOI]
019. "Evolutionary related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion"
Ka Man Carmen Chan, Ashley L. Arthur, Johannes Morstein, Meiyan Jin, Abrar Bhat, Dörte Schlesinger, Sungmin Son, Donté A. Stevens, David G. Drubin, Daniel A. Fletcher, PNAS 2021, 118, e2007526118. [DOI]
018. "Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain"
Xinxin Wang, Hanxiao Liu, Johannes Morstein, Alexander J. E. Novak, Dirk Trauner, Qiaojie Xiong, Yuguo Yu, Shaoyu Ge, PNAS 2020, 117, 25818-25829. [DOI]
017. "Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor Gamma (PPARg)"
Konstantin Hinnah, Sabine Willems, Johannes Morstein, Jan Heering, Felix W. W. Hartrampf, Johannes Broichhagen, Philipp Leippe, Daniel Merk, Dirk Trauner, J. Med. Chem. 2020, 63, 10908-10920. [DOI]
016. "A Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes that Enable Endogenous Carbon Monoxide Detection"
Johannes Morstein, Denis Höfler, Kohei Ueno, Jonah W. Jurss, Ryan R. Walvoord, Kevin J. Bruemmer, Samir P. Rezgui, Thomas F. Brewer, Minoru Saitoe, Brian W. Michel, Christopher J. Chang, J. Am. Chem. Soc. 2020, 142, 15917-15930. [DOI]
015. "Optical Control of Lysophosphatidic Acid Signaling"
Johannes Morstein, Derek Norman, Mèlanie Dacheux, Andrej Shemet, Prashant Donthamsetti, Mevlut Citir, James Frank, Carsten Schultz, Ehud Isacoff, Abby Parrill, Gabor Tigyi, Dirk Trauner, J. Am. Chem. Soc. 2020, 142, 10612-10616. [DOI]
014. "Photopharmacological Control of Lipid Function"
Johannes Morstein, Dirk Trauner, Methods Enzymol. 2020, 638, 219-232. [DOI]
013. "A Photoswitchable Inhibitor of the Human Serotonin Transporter"
Bichu Cheng, Johannes Morstein, Lucy Ladefoged, Jannick Maesen, Birgit Schiøtt, Steffen Sinning, Dirk Trauner, ACS Chem. Neurosci. 2020, 11, 1231-1237. [DOI]
012. "Carbon monoxide, a retrograde messenger generated in post-synaptic mushroom body neurons evokes local dopamine release"
Kohei Ueno, Johannes Morstein, Kyoko Ofusa, Shintaro Naganos, Ema Suzuki-Sawano, Saika Minegishi, Samir P. Rezgui, Hiroaki Kitagishi, Brian W. Michel, Christopher J. Chang, Junjiro Horiuchi, Minoru Saitoe, J. Neurosci. 2020, 40, 3533-3548. [DOI]
011. "Optical Control of the Nuclear Bile Acid Receptor FXR with a Photohormone"
Johannes Morstein, Julie B. Trads, Konstantin Hinnah, Sabine Willems, David M. Barber, Michael Trauner, Daniel Merk, Dirk Trauner, Chem. Sci. 2020, 11, 429-434. [DOI]
010. "Fixing a Photosensitizer Unlocks and Localizes Its Lethality"
Dirk Trauner, Johannes Morstein, ACS Cent. Sci. 2019, 5, 1636-1638. [DOI]
09. "New Players in Photopharmacology: Photopharmacology and Bio-Integrated Optoelectronics"
Johannes Morstein, Dirk Trauner*, Curr. Opin. Chem. Biol. 2019, 50, 145-151. [DOI]
08. "Mapping the Azolog Space Enables the Optical Control of New Biological Targets"
Johannes Morstein, Mahendra Awale, Jean-Louis Reymond, Dirk Trauner, ACS Cent. Sci. 2019, 5, 607-618. [DOI]
07. "Optical Control of Sphingosine-1-Phosphate Formation and Function"
Johannes Morstein, Rose Hill, Alexander Novak, Suihan Feng, Derek Norman, Prashant Donthamsetti, James Frank, Takeshi Harayama, Benjamin Williams, Abby Parrill, Gabor Tigyi, Howard Riezman, Ehud Isacoff, Diana Bautista, Dirk Trauner, Nat. Chem. Bio. 2019, 15, 623-631. [DOI]
06. "Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course"
Kamilah Castro, Achilles Ntranos, Mario Amatruda, Maria Petracca, Peter Kosa, Emily Y. Chen, Johannes Morstein, Dirk Trauner, Corey T. Watson, Michael A. Kiebish, Bibiana Bielekova, Matilde Inglese, Ilana Katz Sand, Patrizia Casaccia, EBioMedicine 2019, 43, 392-410. [DOI]
05. "In Vivo Photopharmacology"
Katharina Hüll, Johannes Morstein, and Dirk Trauner, Chem. Rev. 2018, 118, 10710-10747. [DOI]
04. "Total Synthesis of (±)-Exotine B"
Bichu Cheng, Giulio Volpin, Johannes Morstein, and Dirk Trauner, Org. Lett. 2018, 20, 4358-4361. [DOI]
03. "Copper-Mediated C-N Coupling of Arylsilanes with N-nucleophiles"
Johannes Morstein, Erik D. Kalkman, Christian Bold, Chen Cheng, and John F. Hartwig, Org. Lett. 2016, 18, 5524-5247. [DOI]
02. "Copper-Mediated Trifluoromethylation of Arylsilanes with [(phen)CuCF3]"
Johannes Morstein, Haiyun Hou, Chen Cheng, and John F. Hartwig, Angew. Chem. Int. Ed. 2016, 55, 8054-8057. [DOI]
01. "The dark matter of the cancer genome: Aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations"
Sven Diederichs, Lorenz Bartsch, Julia C. Berkmann, Karin Fröse, Jana Heitmann, Caroline Hoppe, Deetje Iggena, Danny Jazmati, Philipp Karschnia, Miriam Linsenmeier, Thomas Maulhardt, Lino Möhrmann, Johannes Morstein, Stella V. Paffenholz, Jacqueline Platzek, Paula Röpenack, Timo Rückert, Ludger Sandig, Maximilian Schell, Anna Steinmann, Gjendine Voss, Maria E. Weinberger, and Ramona Wullenkord, EMBO Mol. Med. 2016, 8, 442-457. [DOI]